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Stage Two: Genetic Alterations Carcinogenic substances such as nitrosamines, polycyclic aromatic hydrocarbons (PAHs), and formaldehyde cause mutations in oncogenes and tumor suppressors (e.g., p53) present in the DNA of the mouth's lining

Chen H, Li G, Chan YL, Zhang HE, Gorrell MD, Pollock CA, et al

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"Fractionation and Extraction Optimization of Potentially Valuable Compounds and Their Profiling in Six Varieties of Two Nicotiana Species", Molecules 2022, 27(22), 8105